{"product_id":"healthgevity-rejuvenate-senolytic-cellular-renewal","title":"Rejuvenate (Senolytic)","description":"\u003ch1\u003eRejuvenate (Senolytic)\u003cbr\u003e\n\u003c\/h1\u003e\n\u003cp\u003e\u003cspan\u003eis an advanced senolytic and cellular renewal formula delivering ten clinically studied ingredients across five senotherapeutic mechanisms, formulated for once-weekly high-intensity pulse dosing that mirrors the clinical research protocol for senolytic supplementation, designed to support the body's natural clearance of senescent cells, modulate senescence-associated secretory phenotype (SASP) inflammatory signaling, promote autophagy and cellular renewal, support mitochondrial energy and resilience, and provide comprehensive antioxidant and longevity pathway support for the three core biological drivers of accelerated aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eUnderstanding Senolytics and Why Dosing Protocol Matters\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSenescent cells are cells that have stopped dividing and functioning but refuse to undergo apoptosis (programmed cell death). They accumulate with age, chronic stress, inflammation, UV exposure, and environmental burden, and they actively damage the surrounding tissue environment through the senescence-associated secretory phenotype (SASP), a chronic secretion of pro-inflammatory cytokines, matrix metalloproteinases, and growth factors that impairs neighboring healthy cells, accelerates tissue aging, promotes chronic low-grade inflammation known as inflammaging, and drives many of the structural and functional changes associated with biological aging across joints, skin, brain, cardiovascular tissue, and the immune system.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe established research approach to natural senolytic supplementation uses a pulse protocol rather than daily dosing. Senolytics are not daily maintenance supplements. They are taken in brief, high-dose bursts because the goal is to selectively support the elimination of senescent cells that are resistant to normal apoptosis signals, not to suppress a daily biochemical pathway. Taking senolytic compounds daily at low doses produces sustained but subthreshold exposure that does not replicate the burst signaling that distinguishes healthy cells from senescent ones. The once-weekly pulse protocol used in Rejuvenate is the clinically aligned approach, providing the concentrated weekly exposure that characterizes the most rigorous senolytic research designs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eThree Core Aging Problems Rejuvenate Addresses\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSenescent cell accumulation: aging zombie cells that stop functioning but remain metabolically active, releasing SASP factors that signal neighboring healthy cells to begin aging prematurely.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSASP signaling disruption: the chronic, low-grade inflammatory secretome that senescent cells release, contributing to inflammaging, impaired tissue regeneration, declining immune surveillance, and accelerated biological aging throughout the body.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDecline in cellular turnover and NAD+: slowed autophagy, weakened mitochondrial repair, declining NAD+ availability for sirtuin and PARP longevity enzyme activity, and reduced efficiency of the cellular quality control processes that maintain tissue vitality.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRejuvenate addresses all three simultaneously through its ten-ingredient senotherapeutic system. Refer to the product label for exact milligram supplement facts per ingredient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDosing Protocol: Take once weekly as a high-intensity pulse dose. This is a senolytic formula, not a daily supplement. Once-weekly dosing is intentional and clinically aligned with the research approach to senolytic supplementation.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eKey Benefits:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 flex flex-col gap-1 pl-8 mb-3 list-disc\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eSupports the body's natural clearance of senescent cells through fisetin and quercetin senolytic activity\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eHelps maintain healthy SASP inflammatory signaling balance and reduces inflammaging burden\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003ePromotes autophagy and cellular self-cleaning via Spermidine (Puremidine) polyamine activity\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eSupports mitochondrial health, energy metabolism, and cellular resilience\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eL-Ergothioneine (MitoPrime) provides specialized mitochondrial antioxidant protection and telomere maintenance support\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eSenactiv supports natural clearance of aged muscle cells and mitochondrial energy for muscle recovery and endurance\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eTurmiPure GOLD delivers 24x greater curcuminoid absorption for SASP modulation and cellular antioxidant defense\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eCurcuPrime tetrahydrocurcumin provides the active curcumin metabolite for cellular detoxification and sustained antioxidant coverage\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eApigenin supports NAD+ preservation through CD38 inhibition for sustained longevity enzyme activity\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eLuteolin provides antioxidant, photoprotective, and cellular signaling support alongside apigenin\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eEGCG from green tea supports cellular metabolism, stress resilience, and broad-spectrum longevity pathways\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eQuercetin Phytosome (Quercefit) provides 20x bioavailability quercetin for immune modulation, vascular integrity, and antioxidant defense\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eAstraGin enhances absorption across all active ingredients and supports gut barrier integrity\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eOnce-weekly pulse dosing mirrors the clinical senolytic research protocol\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eTen complementary mechanisms in one formula\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eWhat's Inside — Full Ingredient Breakdown (refer to product label for exact mg per serving):\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eFisetin\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA naturally occurring polyphenol concentrated in strawberries, apples, and onions and one of the most researched natural senolytic compounds currently studied. Fisetin's senolytic activity is attributed to its ability to modulate BCL-2 family anti-apoptotic proteins that senescent cells rely on for survival, making these cells more susceptible to the body's normal apoptotic clearance mechanisms while leaving healthy non-senescent cells unaffected. Fisetin also provides direct antioxidant activity, flavonoid-mediated NF-kB modulation, and support for healthy cognition and neurological longevity pathways through brain-penetrant polyphenol activity. It is the lead senolytic compound in Rejuvenate and is most clinically effective at the high-pulse concentrations the once-weekly dosing protocol provides.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eQuercetin Phytosome (Quercefit)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eIndena's patented quercetin phytosome delivering 20x greater bioavailability versus standard quercetin aglycone. Quercetin is the second major senolytic polyphenol in Rejuvenate, complementing fisetin's BCL-2 pathway activity through distinct but overlapping senescent cell clearance mechanisms. Beyond its senolytic role, Quercefit provides broad antioxidant defense, NF-kB and AP-1 inflammatory pathway modulation, mast cell stabilization, immune regulatory activity, and vascular endothelial integrity support, making it one of the most clinically multifunctional ingredients in the formula.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSpermidine (Puremidine)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA naturally occurring polyamine produced endogenously and found in wheat germ, fermented foods, aged cheeses, and mushrooms, with documented roles in inducing autophagy, the cellular self-cleaning process that degrades and recycles damaged organelles, misfolded proteins, and aged mitochondria. Spermidine's autophagy-inducing activity operates through inhibition of the EP300 acetyltransferase, which suppresses autophagy when active. Declining intracellular spermidine levels are directly correlated with age-related autophagy decline, and supplemental spermidine restores autophagic flux. Puremidine is the standardized, high-purity spermidine ingredient providing consistent and documented spermidine delivery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSenactiv (Panax notoginseng Root + Rosa roxburghii Fruit Extracts)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA patented combination from NuLiv Science targeting a dimension of cellular aging specific to muscle tissue: the accumulation of aged, underperforming muscle cells (senescent myocytes) that compete with healthy satellite cells for resources and impair muscle regeneration. Senactiv supports the natural clearance of these aged muscle cells, promotes satellite cell activity for muscle renewal, and supports mitochondrial biogenesis and ATP production in exercising muscle. Human clinical research on Senactiv documents improvements in endurance performance, reduced exercise-associated muscle damage markers, and accelerated post-exercise recovery versus placebo.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eL-Ergothioneine (MitoPrime)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA rare thiohistidine betaine antioxidant with a dedicated cellular transporter (OCTN1\/SLC22A4) that concentrates it specifically in high-metabolic-demand tissues including mitochondria, liver, red blood cells, and neurons. Ergothioneine is increasingly recognized in longevity research for its role in telomere maintenance, mitochondrial DNA integrity, cellular stress resilience, and its correlation with healthy aging outcomes in epidemiological research. MitoPrime is the highest-purity L-Ergothioneine available. In the senolytic context, ergothioneine provides protective antioxidant support within the mitochondria that senescent cells have destabilized, protecting neighboring healthy cells from the oxidative spillover of SASP activity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eTurmiPure GOLD (High-Bioavailability Curcuminoid Complex)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA clinically advanced curcuminoid formulation delivering 24x greater absorption of curcuminoids versus standard curcumin extract. In Rejuvenate, TurmiPure GOLD addresses the SASP directly: curcuminoids at effective absorbed concentrations modulate NF-kB transcription factor activity, reducing the downstream production of the pro-inflammatory cytokines and matrix metalloproteinases that constitute the SASP secretome and drive inflammaging and neighboring tissue damage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eCurcuPrime (Tetrahydrocurcumin)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eThe primary active metabolite of curcumin delivered directly for consistent bioavailability independent of individual metabolic conversion. CurcuPrime provides more potent direct antioxidant activity than parent curcumin through greater radical scavenging capacity, Nrf2 pathway activation for Phase II detoxification enzyme induction, and complementary SASP modulation activity. Together with TurmiPure GOLD, CurcuPrime provides a dual curcuminoid system covering both the acute NF-kB activity of parent curcumin and the sustained antioxidant and detoxification activity of the active metabolite.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eApigenin\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA flavone found in chamomile, parsley, and celery with a specific and increasingly recognized role in NAD+ homeostasis through CD38 inhibition. CD38 is an ectoenzyme whose expression increases dramatically with age and whose activity consumes NAD+ at rates that significantly contribute to the age-related NAD+ decline that impairs sirtuin and PARP longevity enzyme activity. By supporting healthy CD38 regulation, apigenin helps maintain NAD+ availability for downstream longevity and cellular repair pathways, complementing the senolytic and autophagy-inducing activity of the other ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eLuteolin\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eA flavone providing synergistic antioxidant, photoprotective, and cellular signaling support alongside apigenin. Luteolin provides NF-kB inhibitory activity through flavone-mediated pathways, complementing curcumin's NF-kB modulation, and contributes to the broad-spectrum antioxidant environment that protects healthy cells from the oxidative burden of senescent cell SASP secretion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eEGCG (Epigallocatechin Gallate, from Green Tea)\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003eThe primary catechin in green tea, providing broad-spectrum support for cellular metabolism, antioxidant defense, senescence modulation, and longevity signaling pathways through AMPK activation, Nrf2 induction, telomerase activity support, and synergistic antioxidant activity that complements the polyphenol network already present in the formula.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eAstraGin (Astragalus membranaceus + Panax notoginseng Root Extracts) — 50 mg\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003ePatented absorption-enhancing botanical combination that upregulates intestinal nutrient transporter proteins for consistent, enhanced bioavailability of Rejuvenate's active polyphenol compounds across individuals with varying gastrointestinal function, and supports gut barrier integrity and healthy intestinal immune tone.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eStore in a cool, dry place. Keep out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTake once weekly as directed on the product label, or as recommended by your healthcare professional. This is a senolytic pulse formula. Once-weekly dosing is clinically intentional and should not be converted to daily use. Consistent weekly use is recommended for progressive cellular renewal support.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eConsult your healthcare professional before use if pregnant, nursing, taking medications, or have a medical condition.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cem\u003eHealthgevity Rejuvenate is a practitioner-trusted senolytic and cellular renewal supplement available at SOLUDE Wellness \u0026amp; Beauty. It contains Fisetin, Quercetin Phytosome (Quercefit, 20x bioavailability), Spermidine (Puremidine), Senactiv (Panax notoginseng and Rosa roxburghii), L-Ergothioneine (MitoPrime), TurmiPure GOLD (24x curcuminoid absorption), CurcuPrime (Tetrahydrocurcumin), Apigenin, Luteolin, EGCG from Green Tea, and AstraGin 50 mg per once-weekly pulse serving. It is designed to support the body's natural clearance of senescent cells via fisetin and quercetin senolytic activity, healthy SASP inflammatory signaling balance and inflammaging reduction, autophagy and cellular renewal via Spermidine polyamine activity, mitochondrial energy and resilience, aged muscle cell clearance and recovery via Senactiv, telomere maintenance and mitochondrial antioxidant protection via MitoPrime ergothioneine, NAD+ preservation via apigenin CD38 inhibition, cellular detoxification and Nrf2 activity via CurcuPrime, and broad longevity pathway support via EGCG, luteolin, and AstraGin bioavailability enhancement. Once-weekly pulse dosing clinically aligned with senolytic research protocol.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eThese statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!----\u003e","brand":"Healthgevity","offers":[{"title":"Default Title","offer_id":45802724884524,"sku":null,"price":124.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0617\/6122\/4748\/files\/Healthgevityproducts_3_1080x_ce6838cf-5c78-474d-b9a4-79acf4b0a4d6.webp?v=1784051821","url":"https:\/\/soludebewell.com\/products\/healthgevity-rejuvenate-senolytic-cellular-renewal","provider":"Solude","version":"1.0","type":"link"}