{"product_id":"xymogen-methyl-protect-methylation-homocysteine-support","title":"Methyl Protect 60c","description":"\u003ch1\u003e\u003cstrong\u003eMethyl Protect\u003c\/strong\u003e\u003c\/h1\u003e\n\u003cp\u003eis a comprehensive, five-ingredient methylation support formula delivering activated, coenzymated forms of four essential B vitamins alongside Betaine Anhydrous (Trimethylglycine) in a single daily capsule, designed to optimize the methylation cycle, support healthy homocysteine metabolism, promote cardiovascular and neurological health, and support the methylation-dependent detoxification of estrogen, dopamine, epinephrine, and environmental toxins.\u003c\/p\u003e\n\u003cp\u003eMethylation is one of the most fundamental and far-reaching biochemical processes in human biology. It involves the transfer of a methyl group (one carbon atom bonded to three hydrogen atoms) to proteins, enzymes, DNA, neurotransmitters, hormones, and amino acids, influencing gene expression, cellular repair, detoxification, neurotransmitter synthesis and breakdown, immune regulation, and the metabolism of virtually every major hormone and toxin the body processes. When methylation is impaired — whether through MTHFR genetic variants, nutrient depletion, or chronic stress — the consequences show up across every system: elevated homocysteine (a cardiovascular and neurological risk marker), impaired detoxification, hormonal imbalance, mood instability, cognitive decline, and accelerated cellular aging.\u003c\/p\u003e\n\u003cp\u003eThe five nutrients in Methyl Protect address the methylation cycle at every critical enzymatic step. Folate as both Calcium Folinate and Quatrefolic 5-MTHF provides the activated folate that directly enters the methylation cycle without requiring MTHFR conversion — the enzyme that is impaired in individuals with common MTHFR variants. Methylcobalamin provides the active B12 form that donates methyl groups in the methylation of homocysteine to methionine. Betaine Anhydrous (TMG) provides an independent methyl donor for homocysteine methylation through the BHMT pathway, supporting healthy homocysteine levels through a complementary route that does not require folate or B12. Pyridoxal 5-Phosphate (active B6) supports the transsulfuration pathway that metabolizes homocysteine when it is not remethylated. And Riboflavin 5-Phosphate (active B2) supports the enzymatic efficiency of MTHFR itself, optimizing the folate conversion that is central to the entire cycle.\u003c\/p\u003e\n\u003cp\u003eThis is a genuinely comprehensive methylation formula, not a simple B12 or folate supplement. It covers every major branch of the methylation and homocysteine metabolism network in one daily capsule. Available in 60 and 120 capsule sizes. Formulated to exclude wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, GMO-derived ingredients, artificial colors, artificial sweeteners, and artificial preservatives. NSF GMP-certified XYMOGEN professional formula.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Benefits:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports optimal methylation across the full methylation cycle\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports healthy homocysteine levels already within the normal range\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports cardiovascular health through healthy homocysteine metabolism\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports neurological health and healthy nerve function\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports healthy methylation of estrogen, dopamine, epinephrine, and environmental toxins\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports healthy gene expression and DNA methylation\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports cognitive function, mood stability, and emotional balance\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports MTHFR variant individuals with pre-converted active folate forms\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports adrenal health through methylation-dependent neurotransmitter and hormone metabolism\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eDual-form folate (Calcium Folinate and Quatrefolic 5-MTHF) for enhanced bioactivity\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eAll five nutrients in activated, coenzymated forms for immediate bioavailability\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eNo synthetic folic acid — activated folate only\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eBetaine Anhydrous (TMG) 500 mg as an independent methyl donor alongside folate\/B12\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFormulated to exclude gluten, dairy, soy, GMOs, and artificial ingredients\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eNSF GMP-certified XYMOGEN professional formula\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWhat's Inside — Full Supplement Facts (per 1-capsule serving):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRiboflavin (as Riboflavin 5-Phosphate Sodium) — 25 mg (1,923% DV)\u003c\/strong\u003e — The active coenzyme form of Vitamin B2. Riboflavin 5-Phosphate (R5P) is the immediately bioavailable form that bypasses the conversion step required by standard riboflavin. R5P is a required cofactor for MTHFR (methylenetetrahydrofolate reductase), the key enzyme that converts folate to its active 5-MTHF form. When riboflavin status is adequate, MTHFR activity is maximized, supporting the folate-dependent methylation of homocysteine. R5P also supports the electron transport chain, glutathione recycling, and the activation of B6 and folate throughout the B vitamin network.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin B6 (as Pyridoxal 5-Phosphate) — 10 mg (588% DV)\u003c\/strong\u003e — The active coenzyme form of B6. Pyridoxal 5-Phosphate (P5P) supports the transsulfuration pathway, the metabolic route through which homocysteine is converted to cystathionine and ultimately to cysteine (a glutathione precursor) when it is not remethylated. P5P is also the cofactor for neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine) and is involved in approximately 100 additional enzymatic reactions throughout the body.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFolate — 3,400 mcg DFE \/ 850% DV (as Calcium Folinate 1,700 mcg DFE and Quatrefolic (6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt 1,700 mcg DFE)\u003c\/strong\u003e — A dual-form active folate providing both Calcium Folinate (the calcium salt of folinic acid, a biologically active folate form that converts readily to 5-MTHF without MTHFR) and Quatrefolic (the registered trademark for (6S)-5-Methyltetrahydrofolic acid glucosamine salt, the most bioavailable, soluble, and stable form of active methylfolate available). Together these two folate forms deliver 3,400 mcg DFE of immediately active folate that directly participates in the methylation cycle without the MTHFR conversion step required by folic acid or folinic acid alone. No synthetic folic acid. Suitable for individuals with MTHFR variants. Quatrefolic is produced under U.S. patent 7,947,662.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin B12 (as Methylcobalamin) — 1,000 mcg (41,667% DV)\u003c\/strong\u003e — The pre-methylated, bioidentical form of B12. Methylcobalamin directly donates methyl groups in the B12-dependent methylation of homocysteine to methionine (the methionine synthase reaction), making it the most physiologically relevant form of B12 for methylation support and the form preferred over cyanocobalamin for neurological applications. At 1,000 mcg, this delivers a meaningful therapeutic dose for individuals with B12 insufficiency, absorption impairment, or elevated methylation demands.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBetaine Anhydrous (Trimethylglycine \/ TMG) — 500 mg\u003c\/strong\u003e — An osmolyte and methyl donor derived from beet root. TMG donates methyl groups through the BHMT (betaine-homocysteine S-methyltransferase) enzyme pathway, converting homocysteine to methionine through a completely independent route from the folate and B12-dependent pathway. This makes TMG a complementary methyl donor that supports healthy homocysteine levels even when the folate-B12 pathway is impaired, and that adds additional methylation capacity for individuals with high methylation demands. TMG also supports liver function, cellular hydration, and healthy inflammatory balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther Ingredients:\u003c\/strong\u003e Capsule (hypromellose and water), stearic acid, microcrystalline cellulose, silica, magnesium stearate, and medium-chain triglyceride oil. Vegetarian capsule.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStore in a cool, dry place. Keep out of reach of children.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1 capsule once or twice daily, or as directed by your healthcare professional.\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Not recommended during pregnancy without practitioner guidance. Do not use if tamper seal is damaged.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cem\u003eXYMOGEN Methyl Protect is a practitioner-trusted methylation support supplement available at SOLUDE Wellness \u0026amp; Beauty. It contains Riboflavin (as Riboflavin 5-Phosphate Sodium) 25 mg, Vitamin B6 (as Pyridoxal 5-Phosphate) 10 mg, Folate 3,400 mcg DFE (as Calcium Folinate 1,700 mcg DFE and Quatrefolic (6S)-5-Methyltetrahydrofolic Acid Glucosamine Salt 1,700 mcg DFE), Vitamin B12 (as Methylcobalamin) 1,000 mcg, and Betaine Anhydrous (Trimethylglycine) 500 mg per capsule, in a vegetarian hypromellose capsule with stearic acid, microcrystalline cellulose, silica, magnesium stearate, and MCT oil. It is designed to support optimal methylation, healthy homocysteine levels, cardiovascular health, neurological health, healthy methylation of estrogen dopamine epinephrine and environmental toxins, gene expression, cognitive function, mood stability, and adrenal health. Dual-form active folate (Calcium Folinate and Quatrefolic 5-MTHF) with no synthetic folic acid. All five nutrients in activated coenzymated forms. Suitable for MTHFR variants. Formulated to exclude gluten, dairy, soy, GMOs, and artificial ingredients. NSF GMP-certified. 60 vegetarian capsules. Take 1 capsule once or twice daily.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThese statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n\u003c!----\u003e","brand":"Xymogen","offers":[{"title":"Default Title","offer_id":43641584910380,"sku":"SLD-XYM-METHP-60","price":41.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0617\/6122\/4748\/files\/Methyl-Protect-60c-300000996-HIRES-110624.png?v=1779226904","url":"https:\/\/soludebewell.com\/products\/xymogen-methyl-protect-methylation-homocysteine-support","provider":"Solude","version":"1.0","type":"link"}