Protect+ 5

is a comprehensive fat-soluble vitamin synergy formula delivering the four essential fat-soluble vitamins, K2 (as K2VITAL Delta MK-7, the world's only double-microencapsulated vitamin K2), D3 (5,000 IU Cholecalciferol), Vitamin A (Retinol), and Vitamin E (d-alpha Tocopherol), alongside AstraGin for absorption optimization, in a single daily formula designed to provide the foundational fat-soluble vitamin infrastructure for bone health, vascular calcification defense, immune function, cellular renewal, and lipid-soluble antioxidant protection that every other longevity intervention builds upon.

Fat-soluble vitamins do not work in isolation. Their biological functions are deeply interconnected, and supplementing one without the others creates imbalances that reduce efficacy and, in the case of high-dose D3, can create meaningful clinical risks. Vitamin D3 drives calcium absorption in the gut but without Vitamin K2 to activate the osteocalcin and Matrix Gla Protein (MGP) that direct calcium appropriately, D3-mobilized calcium can deposit in arterial walls and soft tissue rather than bone matrix. Vitamins D3 and A share nuclear receptor pathways, both acting through the retinoid X receptor (RXR) and requiring each other for optimal downstream gene expression. Vitamin E, as the body's primary lipid-soluble antioxidant integrated directly into cell membranes and lipoproteins, stabilizes Vitamins A and D3 from oxidative degradation in the fat-soluble cellular environment and extends their effective activity.

Protect+ 5 delivers all four in their most bioavailable, clinically validated forms — the full fat-soluble vitamin system in one capsule, rather than the partial approach of D3-K2 combinations that leave the Vitamin A and E dimensions unaddressed.

The "5" in Protect+ 5 refers to 5,000 IU of Vitamin D3, positioning this as the mid-dose fat-soluble vitamin formula for clients with suboptimal D3 status, limited sun exposure, or moderate therapeutic D3 needs. Protect+ 10 provides the same K2VITAL Delta, Vitamin A, Vitamin E, and AstraGin formula at 10,000 IU D3 for clients with documented significant deficiency or higher therapeutic D3 requirements under practitioner supervision.

Caution: Individuals taking more than 50 mcg (2,000 IU) of Vitamin D per day should have their Vitamin D levels monitored. Use under the supervision of your healthcare professional. Periodic Vitamin D lab monitoring is recommended.

Refer to the product label for exact milligram supplement facts for Vitamins A and E per serving.

Key Benefits:

• K2VITAL Delta MK-7 300 mcg directs calcium into bone and away from arteries via osteocalcin and Matrix Gla Protein activation
• The world's only double-microencapsulated K2 MK-7 maintains 99.7% all-trans isomer purity and mineral stability
• D3 5,000 IU supports calcium absorption, immune gene expression, mood, neurological health, and cellular signaling
• Vitamins D3 and K2 together address both bone health and vascular calcification defense through sequential and complementary mechanisms
• Vitamin A (Retinol) supports cell differentiation, tissue renewal, mucosal barrier integrity, and immune function via shared D3 nuclear receptor pathways
• Vitamin E (d-alpha Tocopherol) provides primary lipid-soluble antioxidant defense in cell membranes and lipoproteins
• Vitamin E stabilizes and extends the effective activity of Vitamins A and D3 in the fat-soluble cellular environment
• AstraGin 50 mg supports fat-soluble vitamin intestinal absorption and gut barrier integrity
• Supports healthy calcium metabolism and bone density
• Supports vascular flexibility and arterial calcification defense
• Supports immune function and balanced inflammatory response
• Complete fat-soluble vitamin synergy — K2, D3, A, and E together rather than in isolation
• Use under healthcare professional supervision with periodic Vitamin D monitoring

What's Inside — Full Supplement Facts (refer to product label for Vitamin A and E exact mg):

K2VITAL Delta (Vitamin K2 as MK-7, Double Microencapsulated) — 300 mcg
K2VITAL Delta by Balchem (formerly Kappa Bioscience) is the most advanced Vitamin K2 MK-7 ingredient available and the world's first and only patented double-microencapsulated K2 preparation. The distinction matters clinically: Vitamin K2 MK-7 is naturally sensitive to degradation in the presence of minerals (calcium, magnesium), alkaline environments, and manufacturing pressure. Independent testing across hundreds of commercial K2 products found that most contain significantly less K2 than their labels claim due to degradation during manufacturing, blending, and storage. K2VITAL Delta's double-coating microencapsulation technology achieves MK-7 recovery rates above 95% in calcium and mineral formulations where conventional K2 would degrade significantly, validated across more than 400 finished product tests. It also maintains a minimum 99.7% all-trans isomer purity, the fully bioactive form identical to the K2 molecule found in nature. Cis-isomers found in lower-quality K2 preparations are not biologically active. At 300 mcg, this provides the upper end of the clinically studied supplemental MK-7 range for both osteocalcin-mediated bone matrix mineralization and MGP-mediated arterial calcification defense. A 2024 peer-reviewed study published in the Journal of the American College of Cardiology documented that Vitamin K2 MK-7 combined with Vitamin D3 significantly impeded progression of coronary artery calcification, directly validating this formula's D3 and K2 combination approach.

Vitamin D3 (as Cholecalciferol) — 125 mcg (5,000 IU)
The form of Vitamin D3 synthesized in human skin upon UVB exposure and structurally identical to the D3 the body produces naturally. At 5,000 IU, Protect+ 5 provides a clinically meaningful mid-dose for adults with suboptimal vitamin D status due to limited sun exposure, northern latitude residence, darker skin pigmentation, age-related declining synthesis efficiency, or moderate absorption limitations. D3 supports calcium absorption in the gut, activates gene expression across immune cells (T-cells, macrophages, B-cells), supports mood and neurological health through VDR receptor activity in the brain, and regulates the calcium homeostasis signaling that K2's osteocalcin and MGP then direct into the appropriate tissues. D3 also shares the retinoid X receptor (RXR) pathway with Vitamin A, meaning both vitamins are needed for optimal downstream gene expression through their respective nuclear receptor heterodimers. Periodic Vitamin D lab monitoring (25-OH Vitamin D) is recommended at this dose.

Vitamin A (as Retinol)
The preformed, immediately bioavailable form of Vitamin A, working alongside D3 through shared RXR nuclear receptor pathways for optimal gene expression. Vitamin A supports cell differentiation and renewal across skin, respiratory, intestinal, and immune tissue, mucosal barrier integrity throughout the gut and respiratory tract, immune function via T-cell and NK cell differentiation, bone metabolism through regulation of osteoblast and osteoclast activity, and visual function through retinal photoreceptor activity. Vitamin A and D3 have a functional interdependency at the nuclear receptor level that makes their co-supplementation more effective than either vitamin in isolation.

Vitamin E (as d-alpha Tocopherol)
The natural, most bioactive form of Vitamin E, serving as the body's primary lipid-soluble chain-breaking antioxidant. Vitamin E integrates directly into the phospholipid bilayer of cell membranes and into circulating lipoproteins where it interrupts lipid peroxidation chain reactions before they propagate through membrane lipid layers. This membrane-integrated activity protects Vitamins A and D3 from oxidative degradation in their fat-soluble biological environment, extending their effective circulating activity. Vitamin E also provides immunomodulatory activity through effects on T-cell signaling, prostaglandin metabolism, and natural killer cell function, and has been studied for its role in supporting healthy cognitive aging and cardiovascular cellular integrity.

AstraGin (Astragalus membranaceus + Panax notoginseng Root Extracts) — 50 mg
Patented absorption-enhancing combination that upregulates intestinal nutrient transporter proteins to support the consistent and efficient absorption of fat-soluble vitamins K2, D3, A, and E across the intestinal wall. Fat-soluble vitamins require bile acid micellization, pancreatic lipase activity, and specific intestinal transporters for absorption, and AstraGin supports the expression of these transport systems for enhanced bioavailability. AstraGin also supports gut barrier integrity, contributing to the absorptive surface health that determines fat-soluble vitamin bioavailability at the fundamental cellular level.

Storage

Store in a cool, dry place. Keep out of reach of children.

Directions

Take as directed on the product label or as recommended by your healthcare professional. Best taken with a fat-containing meal to support fat-soluble vitamin absorption.

Individuals taking more than 50 mcg (2,000 IU) of Vitamin D per day should have their Vitamin D levels monitored. Use under the supervision of your healthcare professional. Not intended for long-term use without practitioner guidance. Consult your healthcare professional before use if pregnant, nursing, taking anticoagulant medications, or have a medical condition. Vitamin K2 may interact with warfarin and anticoagulant therapy.

Healthgevity Protect+ 5 is a practitioner-trusted fat-soluble vitamin synergy supplement available at SOLUDE Wellness & Beauty. It contains K2VITAL Delta (Vitamin K2 as MK-7, double microencapsulated, 99.7% all-trans) 300 mcg, Vitamin D3 (Cholecalciferol) 125 mcg (5,000 IU), Vitamin A (Retinol), Vitamin E (d-alpha Tocopherol), and AstraGin (Astragalus membranaceus and Panax notoginseng) 50 mg per serving. It is designed to support healthy calcium metabolism and bone density via K2 osteocalcin activation, vascular calcification defense via K2 Matrix Gla Protein activation, calcium absorption and immune gene expression via D3 5000 IU, cell differentiation tissue renewal and mucosal immunity via Vitamin A, lipid-soluble antioxidant membrane protection via Vitamin E, fat-soluble vitamin stabilization via Vitamin E, shared nuclear receptor pathway synergy between D3 and A, and fat-soluble vitamin absorption via AstraGin. K2VITAL Delta is the world's only double-microencapsulated K2 MK-7 with confirmed mineral stability and 99.7% all-trans purity. Use under practitioner supervision with periodic Vitamin D monitoring.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.