is a four-strain spore-based probiotic delivering 4 billion CFU per capsule from DE111 (Bacillus subtilis), CS108/MuniSpore (Bacillus clausii), Bacillus subtilis Bss-19, and Bacillus coagulans SANK 70258, in a clean vegetarian capsule designed for shelf-stable, refrigeration-free, stomach acid-resistant daily gut microbiome support for clients who need the unique resilience, stability, and clinical profile of spore-forming Bacillus species rather than traditional Lactobacillus and Bifidobacterium probiotics.

Spore-based probiotics and traditional Lactobacillus and Bifidobacterium probiotics are fundamentally different categories of organisms. Lactobacillus and Bifidobacterium species are vegetative bacteria that require refrigeration, are vulnerable to oxygen and heat, and survive stomach acid transit at variable rates depending on the delivery technology used. Bacillus species produce a protective endospore, a protein coat around the bacterial cell that allows the organism to exist in a dormant, highly resistant state that survives stomach acid, heat, UV radiation, oxygen, and environmental stress without any special delivery technology, enteric coating, or cold chain. This endospore is not a manufacturing protection strategy — it is the organism's natural evolutionary adaptation for surviving hostile environments before germinating and becoming active when conditions are favorable.

When a Bacillus spore reaches the small intestine, where the pH rises and the environment becomes more hospitable, it germinates, activates, and begins performing the enzymatic, antimicrobial, and immunomodulatory functions that make these organisms clinically valuable. This means that every CFU consumed from ProbioMax Spore reaches the site of action with near-complete viability, unlike traditional probiotics where gastric survival rates vary significantly. At 4 billion CFU total from four Bacillus strains, the effective delivered dose of ProbioMax Spore compares favorably to much higher CFU counts from traditional probiotic formats.

The four strains were selected specifically for their complementary profiles. DE111 (Bacillus subtilis), the most extensively researched spore probiotic strain available, anchors the formula with its broad clinical documentation. CS108 (Bacillus clausii), also known as MuniSpore, is particularly notable for its antibiotic-resistant properties, making it one of the few probiotic strains that can be taken concurrently with antibiotic therapy. The DuoPro HOWARU blend adds Bacillus subtilis Bss-19 and Bacillus coagulans SANK 70258, the latter being one of the most studied Bacillus coagulans strains for digestive and bowel regularity support.

No refrigeration required. Shelf stable at room temperature. Suitable during antibiotic use with practitioner guidance. Vegetarian, free from animal products, dairy, egg, fish, gluten, soy, peanuts, tree nuts, sesame, shellfish, and GMOs. 30 capsules, 30 servings.

Key Benefits:

• Spore-forming Bacillus strains survive stomach acid intact with near-complete viability
• No special delivery technology, enteric coating, or refrigeration needed due to natural endospore protection
• Supports healthy gut microbiome balance and digestive health
• Supports bowel regularity via DE111 and SANK 70258 clinical documentation
• Supports GI comfort including reduction of occasional constipation and digestive discomfort
• Bacillus clausii CS108 / MuniSpore is antibiotic-resistant and can be used during antibiotic therapy
• DE111, the most extensively researched Bacillus subtilis strain, at 2 billion CFU
• Produces enzymes, antimicrobial compounds, vitamins, and carotenoids in the gut environment
• Supports immune function through gut-associated immune modulation
• Particularly appropriate for those on CellCore detox protocols, travelers, active detox phases, and clients who cannot refrigerate supplements
• Shelf stable, room temperature stable, travel-ready
• Vegetarian, free from gluten, dairy, soy, GMOs, and common allergens

Bacillus subtilis DE111 — 18.2 mg (2 Billion CFU) — DE111 is a patented, identity-certified Bacillus subtilis strain registered trademark of Deerland Probiotics and Enzymes, and the most extensively documented spore-based probiotic strain available in a daily supplement. Multiple human clinical trials on DE111 have demonstrated support for bowel regularity (significant improvement in GI discomfort, constipation, diarrhea, and frequency of normal stools over a 105-day study), healthy gut microbiome composition, healthy immune function, and body composition support. B. subtilis DE111 produces a broad spectrum of antimicrobial compounds including iturin, surfactin, and bacillomycin, as well as enzymes, vitamins, and carotenoids in the gut environment. At 2 billion CFU, DE111 provides the anchor dose for this formula.

Bacillus clausii CS108 / MuniSpore — 9.1 mg (1 Billion CFU) — CS108, also known as MuniSpore, is a Deerland-registered trademark Bacillus clausii strain with a particularly distinctive clinical property: antibiotic resistance. Bacillus clausii is one of the very few probiotic organisms that maintains viability during concurrent antibiotic therapy, making it the only strain in this formula that practitioners can recommend to clients mid-antibiotic course without concern for antibiotic-mediated killing. CS108 supports microbiome restoration after antibiotic disruption and provides immune modulation and gut protective activity.

Bacillus subtilis Bss-19 — A HOWARU identity-certified Bacillus subtilis strain providing complementary B. subtilis species diversity alongside DE111 for additional enzymatic, antimicrobial, and gut environment-supporting activity.

Bacillus coagulans SANK 70258 — One of the most extensively studied Bacillus coagulans strains globally, with a long clinical history particularly in Japan where it has been studied for decades for digestive health, bowel regularity, and immune support. B. coagulans SANK 70258 produces L-lactic acid in the intestine, supporting a healthy gut pH and environment favorable to beneficial bacteria.

Other Ingredients: Microcrystalline cellulose, capsule (hypromellose and water), ascorbyl palmitate, hydroxypropyl cellulose, and silica. Vegetarian capsule. Trademarks: DE111 and MuniSpore are registered trademarks of Deerland Probiotics and Enzymes, Inc. DuoPro/HOWARU is a registered trademark of IFF or its affiliates.

Store in a cool, dry place. No refrigeration required. Shelf stable at room temperature. Keep tightly closed and out of reach of children.

Take 1 capsule daily, or as directed by your healthcare professional. Can be taken with or without food. No refrigeration required.

If pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use.